A highly sensitive assay for glutathione transferase using 4,5-dihydro-epoxybenzo( a)pyrene as substrate

A highly sensitive assay for glutathione transferase using 4,5-dihydro-epoxybenzo( a)pyrene as substrate

In this paper, the authors describe tricyclic antidepressant drug effects on the structure of large multilamellar liposomes prepared from DPPC, DOPC, and egg PC, 1.6-Diphenyl-1,3,5-hexatriene (DPH), a highly lipophilic fluorescent probe (14), has been used to characterize the concentration and tempe...

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Veröffentlicht in:Biochemical pharmacology 1985-03, Vol.34 (5), p.703-705
Hauptverfasser: Hukkelhoven, M.W.A.C., van Pelt, F.N.A.M., Dijkstra, A.C., Vermorken, A.J.M.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
antidepressants
Benzopyrenes
Biological and medical sciences
Carcinogenesis, carcinogens and anticarcinogens
Chemical agents
drugs
electron microscopy
Fluorometry
Glutathione Transferase - analysis
Hair - enzymology
Hydrogen-Ion Concentration
liposomes
Liver - enzymology
Medical sciences
Rats
Tumors
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Zusammenfassung:In this paper, the authors describe tricyclic antidepressant drug effects on the structure of large multilamellar liposomes prepared from DPPC, DOPC, and egg PC, 1.6-Diphenyl-1,3,5-hexatriene (DPH), a highly lipophilic fluorescent probe (14), has been used to characterize the concentration and temperature dependence of drug-induced alterations of liposomal membrane structure. The size of the multilamellar liposomes was determined by electron microscopy.
ISSN:0006-2952
1873-2968
DOI:10.1016/0006-2952(85)90267-9