Polymeric Nanoparticles with Sequential and Multiple FRET Cascade Mechanisms for Multicolor and Multiplexed Imaging

Polymeric Nanoparticles with Sequential and Multiple FRET Cascade Mechanisms for Multicolor and Multiplexed Imaging

The ability to map multiple biomarkers at the same time has far‐reaching biomedical and diagnostic applications. Here, a series of biocompatible poly(d,l‐lactic‐co‐glycolic acid) and polyethylene glycol particles for multicolor and multiplexed imaging are reported. More than 30 particle formulations...

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Veröffentlicht in:Small (Weinheim an der Bergstrasse, Germany) Germany), 2013-06, Vol.9 (12), p.2129-2139
Hauptverfasser: Wagh, Anil, Jyoti, Faidat, Mallik, Sanku, Qian, Steven, Leclerc, Estelle, Law, Benedict
Format: Artikel
Sprache:eng
Schlagworte:
Cascades
Diagnostic Imaging - methods
Emission
Fluorescence
Fluorescence Resonance Energy Transfer - methods
FRET cascades
Fretting
Imaging
Lactic Acid - chemistry
Mathematical models
Medical research
multicolor imaging
multiplexed imaging
Multiplexing
Nanoparticles - chemistry
Nanotechnology
PLGA-PEG nanoparticles
Polyethylene Glycols - chemistry
Polyglycolic Acid - chemistry
Polymers - chemistry
Proteins
Quantum dots
Signatures
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Zusammenfassung:The ability to map multiple biomarkers at the same time has far‐reaching biomedical and diagnostic applications. Here, a series of biocompatible poly(d,l‐lactic‐co‐glycolic acid) and polyethylene glycol particles for multicolor and multiplexed imaging are reported. More than 30 particle formulations that exhibit distinct emission signatures (ranging from the visible to NIR wavelength region) are designed and synthesized. These particles are encapsulated with combinations of carbocyanine‐based fluorophores DiO, Dil, DiD, and DiR, and are characterized as
ISSN:1613-6810
1613-6829
DOI:10.1002/smll.201202655