Defined Polymer-Peptide Conjugates to Form Cell-Instructive starPEG-Heparin Matrices In Situ

Poly(ethylene glycol)‐peptide‐ and glycosaminoglycan‐peptide conjugates obtained by a regio‐selective amino acid protection strategy are converted into cell‐instructive hydrogel matrices capable of inducing morphogenesis in embedded human vascular endothelial cells and dorsal root ganglia.

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Bibliographische Detailangaben
Veröffentlicht in:	Advanced materials (Weinheim) 2013-05, Vol.25 (18), p.2606-2610
Hauptverfasser:	Tsurkan, Mikhail V., Chwalek, Karolina, Prokoph, Silvana, Zieris, Andrea, Levental, Kandice R., Freudenberg, Uwe, Werner, Carsten
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Biocompatible Materials - chemistry Biocompatible Materials - pharmacology biohybrid hydrogels Conjugates dorsal root ganglia Endothelial cells Ganglia Heparin - chemistry Human human umbilical vein endothelial cells Human Umbilical Vein Endothelial Cells - cytology Human Umbilical Vein Endothelial Cells - drug effects Humans Hydrogels Peptides - chemistry Polyethylene Glycols - chemistry Roots Strategy Sulfhydryl Compounds - chemistry vascular endothelial growth factor
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Beschreibung
Zusammenfassung:	Poly(ethylene glycol)‐peptide‐ and glycosaminoglycan‐peptide conjugates obtained by a regio‐selective amino acid protection strategy are converted into cell‐instructive hydrogel matrices capable of inducing morphogenesis in embedded human vascular endothelial cells and dorsal root ganglia.
ISSN:	0935-9648 1521-4095
DOI:	10.1002/adma.201300691