Photoresponsive hyaluronate nanogel as an anticancer drug carrier
In this study, we introduced photolabile 4‐(4‐(1‐hydroxyethyl)‐2‐methoxy‐5‐nitrophenoxy)butyric acid (HMNB) to prepare photoresponsive nanogels. Hyaluronate (HA) grafted with 4‐(4‐(1‐hydroxyethyl)‐2‐methoxy‐5‐nitrophenoxy)butyric acid (HA‐g‐HMNB) was self organized in aqueous solution. Interestingly...
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| Veröffentlicht in: | Polymers for advanced technologies 2013-09, Vol.24 (9), p.791-796 |
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| container_title | Polymers for advanced technologies |
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| creator | Park, SoHyun Oh, Kyung Taek Kwag, Dong Sup Lee, Ung Yeol Lee, Dong Jin Lee, Eun Seong |
| description | In this study, we introduced photolabile 4‐(4‐(1‐hydroxyethyl)‐2‐methoxy‐5‐nitrophenoxy)butyric acid (HMNB) to prepare photoresponsive nanogels. Hyaluronate (HA) grafted with 4‐(4‐(1‐hydroxyethyl)‐2‐methoxy‐5‐nitrophenoxy)butyric acid (HA‐g‐HMNB) was self organized in aqueous solution. Interestingly, HA‐g‐HMNB nanogels exhibited caging and photo‐uncaging properties for an encapsulated antitumor drug. Photoactivation allowed accelerated antitumor drug release from uncaged nanogels. We found a significant improvement in KB tumor‐cell‐killing efficacy when this system was associated with local light irradiation. Copyright © 2013 John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/pat.3143 |
| format | Article |
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Hyaluronate (HA) grafted with 4‐(4‐(1‐hydroxyethyl)‐2‐methoxy‐5‐nitrophenoxy)butyric acid (HA‐g‐HMNB) was self organized in aqueous solution. Interestingly, HA‐g‐HMNB nanogels exhibited caging and photo‐uncaging properties for an encapsulated antitumor drug. Photoactivation allowed accelerated antitumor drug release from uncaged nanogels. We found a significant improvement in KB tumor‐cell‐killing efficacy when this system was associated with local light irradiation. Copyright © 2013 John Wiley & Sons, Ltd.</description><identifier>ISSN: 1042-7147</identifier><identifier>EISSN: 1099-1581</identifier><identifier>DOI: 10.1002/pat.3143</identifier><identifier>CODEN: PADTE5</identifier><language>eng</language><publisher>Chichester: Blackwell Publishing Ltd</publisher><subject>4-(4-(1-hydroxyethyl)-2-methoxy-5-nitrophenoxy)butyric acid (HMNB) ; Applied sciences ; Biological and medical sciences ; Exact sciences and technology ; General pharmacology ; hyaluronate nanogels ; Medical sciences ; Natural polymers ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; photoresponsive nanogels ; Physicochemistry of polymers ; Starch and polysaccharides ; tumor therapy</subject><ispartof>Polymers for advanced technologies, 2013-09, Vol.24 (9), p.791-796</ispartof><rights>Copyright © 2013 John Wiley & Sons, Ltd.</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3943-26221175c9714c8c48f0fb03e9bbc4a79cc2f00e35b4e9fe2aeedd1c570860283</citedby><cites>FETCH-LOGICAL-c3943-26221175c9714c8c48f0fb03e9bbc4a79cc2f00e35b4e9fe2aeedd1c570860283</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fpat.3143$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fpat.3143$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27668576$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Park, SoHyun</creatorcontrib><creatorcontrib>Oh, Kyung Taek</creatorcontrib><creatorcontrib>Kwag, Dong Sup</creatorcontrib><creatorcontrib>Lee, Ung Yeol</creatorcontrib><creatorcontrib>Lee, Dong Jin</creatorcontrib><creatorcontrib>Lee, Eun Seong</creatorcontrib><title>Photoresponsive hyaluronate nanogel as an anticancer drug carrier</title><title>Polymers for advanced technologies</title><addtitle>Polym. Adv. Technol</addtitle><description>In this study, we introduced photolabile 4‐(4‐(1‐hydroxyethyl)‐2‐methoxy‐5‐nitrophenoxy)butyric acid (HMNB) to prepare photoresponsive nanogels. Hyaluronate (HA) grafted with 4‐(4‐(1‐hydroxyethyl)‐2‐methoxy‐5‐nitrophenoxy)butyric acid (HA‐g‐HMNB) was self organized in aqueous solution. Interestingly, HA‐g‐HMNB nanogels exhibited caging and photo‐uncaging properties for an encapsulated antitumor drug. Photoactivation allowed accelerated antitumor drug release from uncaged nanogels. We found a significant improvement in KB tumor‐cell‐killing efficacy when this system was associated with local light irradiation. Copyright © 2013 John Wiley & Sons, Ltd.</description><subject>4-(4-(1-hydroxyethyl)-2-methoxy-5-nitrophenoxy)butyric acid (HMNB)</subject><subject>Applied sciences</subject><subject>Biological and medical sciences</subject><subject>Exact sciences and technology</subject><subject>General pharmacology</subject><subject>hyaluronate nanogels</subject><subject>Medical sciences</subject><subject>Natural polymers</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>photoresponsive nanogels</subject><subject>Physicochemistry of polymers</subject><subject>Starch and polysaccharides</subject><subject>tumor therapy</subject><issn>1042-7147</issn><issn>1099-1581</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNp1kG9LwzAQh4soOKfgRyiI4JvO_GvTvBybm-LQ4Sa-DFl23Tq7Ziatum9vxsoEQTi4g3t4uPsFwSVGHYwQud2oqkMxo0dBCyMhIhyn-Hg3MxJxzPhpcObcCiG_E7wVdMdLUxkLbmNKl39CuNyqoramVBWEpSrNAopQuVCVvqpcq1KDDee2XoRaWZuDPQ9OMlU4uGh6O3gd3E1799HoefjQ644iTQWjEUkIwZjHWvgrdKpZmqFshiiI2UwzxYXWJEMIaDxjIDIgCmA-xzrmKE0QSWk7uNl7N9Z81OAquc6dhqJQJZjaSf-z4JSxNPbo1R90ZWpb-us8RbjgLCHsV6itcc5CJjc2Xyu7lRjJXZbSZyl3WXr0uhEqp1WRWR9D7g484UmSxjzxXLTnvvICtv_65Lg7bbwNn7sKvg-8su8y4ZTH8u1pKMf9dPIyeezLAf0BICiQkg</recordid><startdate>201309</startdate><enddate>201309</enddate><creator>Park, SoHyun</creator><creator>Oh, Kyung Taek</creator><creator>Kwag, Dong Sup</creator><creator>Lee, Ung Yeol</creator><creator>Lee, Dong Jin</creator><creator>Lee, Eun Seong</creator><general>Blackwell Publishing Ltd</general><general>Wiley</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8FD</scope><scope>JG9</scope><scope>7QO</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>201309</creationdate><title>Photoresponsive hyaluronate nanogel as an anticancer drug carrier</title><author>Park, SoHyun ; Oh, Kyung Taek ; Kwag, Dong Sup ; Lee, Ung Yeol ; Lee, Dong Jin ; Lee, Eun Seong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3943-26221175c9714c8c48f0fb03e9bbc4a79cc2f00e35b4e9fe2aeedd1c570860283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>4-(4-(1-hydroxyethyl)-2-methoxy-5-nitrophenoxy)butyric acid (HMNB)</topic><topic>Applied sciences</topic><topic>Biological and medical sciences</topic><topic>Exact sciences and technology</topic><topic>General pharmacology</topic><topic>hyaluronate nanogels</topic><topic>Medical sciences</topic><topic>Natural polymers</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>photoresponsive nanogels</topic><topic>Physicochemistry of polymers</topic><topic>Starch and polysaccharides</topic><topic>tumor therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Park, SoHyun</creatorcontrib><creatorcontrib>Oh, Kyung Taek</creatorcontrib><creatorcontrib>Kwag, Dong Sup</creatorcontrib><creatorcontrib>Lee, Ung Yeol</creatorcontrib><creatorcontrib>Lee, Dong Jin</creatorcontrib><creatorcontrib>Lee, Eun Seong</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Biotechnology Research Abstracts</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Polymers for advanced technologies</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Park, SoHyun</au><au>Oh, Kyung Taek</au><au>Kwag, Dong Sup</au><au>Lee, Ung Yeol</au><au>Lee, Dong Jin</au><au>Lee, Eun Seong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Photoresponsive hyaluronate nanogel as an anticancer drug carrier</atitle><jtitle>Polymers for advanced technologies</jtitle><addtitle>Polym. Adv. Technol</addtitle><date>2013-09</date><risdate>2013</risdate><volume>24</volume><issue>9</issue><spage>791</spage><epage>796</epage><pages>791-796</pages><issn>1042-7147</issn><eissn>1099-1581</eissn><coden>PADTE5</coden><abstract>In this study, we introduced photolabile 4‐(4‐(1‐hydroxyethyl)‐2‐methoxy‐5‐nitrophenoxy)butyric acid (HMNB) to prepare photoresponsive nanogels. Hyaluronate (HA) grafted with 4‐(4‐(1‐hydroxyethyl)‐2‐methoxy‐5‐nitrophenoxy)butyric acid (HA‐g‐HMNB) was self organized in aqueous solution. Interestingly, HA‐g‐HMNB nanogels exhibited caging and photo‐uncaging properties for an encapsulated antitumor drug. Photoactivation allowed accelerated antitumor drug release from uncaged nanogels. We found a significant improvement in KB tumor‐cell‐killing efficacy when this system was associated with local light irradiation. Copyright © 2013 John Wiley & Sons, Ltd.</abstract><cop>Chichester</cop><pub>Blackwell Publishing Ltd</pub><doi>10.1002/pat.3143</doi><tpages>6</tpages></addata></record> |
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| subjects | 4-(4-(1-hydroxyethyl)-2-methoxy-5-nitrophenoxy)butyric acid (HMNB) Applied sciences Biological and medical sciences Exact sciences and technology General pharmacology hyaluronate nanogels Medical sciences Natural polymers Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments photoresponsive nanogels Physicochemistry of polymers Starch and polysaccharides tumor therapy |
| title | Photoresponsive hyaluronate nanogel as an anticancer drug carrier |
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