Photoresponsive hyaluronate nanogel as an anticancer drug carrier

In this study, we introduced photolabile 4‐(4‐(1‐hydroxyethyl)‐2‐methoxy‐5‐nitrophenoxy)butyric acid (HMNB) to prepare photoresponsive nanogels. Hyaluronate (HA) grafted with 4‐(4‐(1‐hydroxyethyl)‐2‐methoxy‐5‐nitrophenoxy)butyric acid (HA‐g‐HMNB) was self organized in aqueous solution. Interestingly...

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Veröffentlicht in:	Polymers for advanced technologies 2013-09, Vol.24 (9), p.791-796
Hauptverfasser:	Park, SoHyun, Oh, Kyung Taek, Kwag, Dong Sup, Lee, Ung Yeol, Lee, Dong Jin, Lee, Eun Seong
Format:	Artikel
Sprache:	eng
Schlagworte:	4-(4-(1-hydroxyethyl)-2-methoxy-5-nitrophenoxy)butyric acid (HMNB) Applied sciences Biological and medical sciences Exact sciences and technology General pharmacology hyaluronate nanogels Medical sciences Natural polymers Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments photoresponsive nanogels Physicochemistry of polymers Starch and polysaccharides tumor therapy
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Beschreibung
Zusammenfassung:	In this study, we introduced photolabile 4‐(4‐(1‐hydroxyethyl)‐2‐methoxy‐5‐nitrophenoxy)butyric acid (HMNB) to prepare photoresponsive nanogels. Hyaluronate (HA) grafted with 4‐(4‐(1‐hydroxyethyl)‐2‐methoxy‐5‐nitrophenoxy)butyric acid (HA‐g‐HMNB) was self organized in aqueous solution. Interestingly, HA‐g‐HMNB nanogels exhibited caging and photo‐uncaging properties for an encapsulated antitumor drug. Photoactivation allowed accelerated antitumor drug release from uncaged nanogels. We found a significant improvement in KB tumor‐cell‐killing efficacy when this system was associated with local light irradiation. Copyright © 2013 John Wiley & Sons, Ltd.
ISSN:	1042-7147 1099-1581
DOI:	10.1002/pat.3143