Insulin antibodies in patients receiving penicillamine

In a patient receiving penicillamine for treatment of rheumatoid arthritis, antibodies to insulin developed, which resulted in symptomatic hypoglycemia. When 30 additional patients receiving penicillamine were screened, another patient was discovered to have antibodies to insulin. The level of antib...

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Veröffentlicht in:	The American journal of medicine 1985-01, Vol.78 (5), p.857-860
Hauptverfasser:	Benson, Edward A., Healey, L.A., Barron, Edward J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult antirheumatic agents Arthritis, Rheumatoid - drug therapy Arthritis, Rheumatoid - immunology autoantibodies Autoantibodies - biosynthesis Biological and medical sciences Female Hormones. Endocrine system Humans hypoglycemia Hypoglycemia - etiology insulin Insulin Antibodies - biosynthesis Male Medical sciences Middle Aged penicillamine Penicillamine - adverse effects Pharmacology. Drug treatments side effects
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Beschreibung
Zusammenfassung:	In a patient receiving penicillamine for treatment of rheumatoid arthritis, antibodies to insulin developed, which resulted in symptomatic hypoglycemia. When 30 additional patients receiving penicillamine were screened, another patient was discovered to have antibodies to insulin. The level of antibody fell sharply in both patients after penicillamine was discontinued. This particular immunologic reaction to penicillamine has not been reported previously.
ISSN:	0002-9343 1555-7162
DOI:	10.1016/0002-9343(85)90294-3