Enhanced Replication of R5 HIV-1 Isolates invitro by a Small-Molecule Reagent Targeting HIV-1 Protease

Enhanced Replication of R5 HIV-1 Isolates invitro by a Small-Molecule Reagent Targeting HIV-1 Protease

CHEMICAL ENHANCEMENT: Designed to target HIV-1 protease, a novel γ-hydroxyphosphonate has been found to significantly enhance viral replication in a panel of clinically relevant R5 HIV-1 isolates. This unexpected result constitutes the first instance of a small molecule capable of doing this, and it...

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Veröffentlicht in:ChemMedChem 2013-05, Vol.8 (5), p.719-721
Hauptverfasser: Wardle, Nick J, Hudson, Harry R, Matthews, Ray W, Nunn, Christine M, Vella, Cherelyn, Bligh, S. W. Annie
Format: Artikel
Sprache:eng ; ger
Schlagworte:
Drug development
Human immunodeficiency virus 1
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Zusammenfassung:CHEMICAL ENHANCEMENT: Designed to target HIV-1 protease, a novel γ-hydroxyphosphonate has been found to significantly enhance viral replication in a panel of clinically relevant R5 HIV-1 isolates. This unexpected result constitutes the first instance of a small molecule capable of doing this, and it has implications for the preparation and use of R5 isolates in vaccine and drug development.
ISSN:1860-7179
1860-7187
DOI:10.1002/cmdc.201300051