Chromatin H3K27me3/H3K4me3 histone marks define gene sets in high-grade serous ovarian cancer that distinguish malignant, tumour-sustaining and chemo-resistant ovarian tumour cells

Chromatin H3K27me3/H3K4me3 histone marks define gene sets in high-grade serous ovarian cancer that distinguish malignant, tumour-sustaining and chemo-resistant ovarian tumour cells

In embryonic stem (ES) cells, bivalent chromatin domains containing H3K4me3 and H3K27me3 marks silence developmental genes, while keeping them poised for activation following differentiation. We have identified gene sets associated with H3K27me3 and H3K4me3 marks at transcription start sites in a hi...

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Veröffentlicht in:Oncogene 2013-09, Vol.32 (38), p.4586-4592
Hauptverfasser: Chapman-Rothe, N, Curry, E, Zeller, C, Liber, D, Stronach, E, Gabra, H, Ghaem-Maghami, S, Brown, R
Format: Artikel
Sprache:eng
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1-Phosphatidylinositol 3-kinase
631/208/2489/2487/2486
631/67/1059/2326
692/699/67/1517/1709
Antineoplastic Agents - pharmacology
Apoptosis
Cell Biology
Chromatin
Chromatin - metabolism
Chromatin Immunoprecipitation
Drug resistance
Drug Resistance, Neoplasm - genetics
Epigenesis, Genetic
Epigenetics
Epigenomics
Female
Gene expression
Gene Expression Regulation, Neoplastic
Gene Silencing
Genetic aspects
High-Throughput Nucleotide Sequencing
Histones
Histones - metabolism
Human Genetics
Humans
Internal Medicine
Medicine
Medicine & Public Health
Neoplasm Grading
oncogenomics
Oncology
Ovarian cancer
Ovarian Neoplasms - genetics
Ovarian Neoplasms - metabolism
Ovarian Neoplasms - pathology
Physiological aspects
Signal transduction
Stem cells
Transcription
Tumors
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Zusammenfassung:In embryonic stem (ES) cells, bivalent chromatin domains containing H3K4me3 and H3K27me3 marks silence developmental genes, while keeping them poised for activation following differentiation. We have identified gene sets associated with H3K27me3 and H3K4me3 marks at transcription start sites in a high-grade ovarian serous tumour and examined their association with epigenetic silencing and malignant progression. This revealed novel silenced bivalent marked genes, not described previously for ES cells, which are significantly enriched for the PI3K ( P
ISSN:0950-9232
1476-5594
DOI:10.1038/onc.2012.477