Effects of Staphylococcus Aureus Supernatants on Human Lymphocyte Surface Receptors

The effects of Staphylococcus aureus proteolytic enzymes on surface receptors of human lymphocytes were studied. Proteolytic activity was detected in 35 supernatants of 45 S. aureus strains. aur and sspA genes were detected by PCR in 43 strains. Incubation of lymphocytes showed reduced expression of...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2013-04, Vol.154 (6), p.765-768
Hauptverfasser:	Tyurin, Yu. A., Mustafin, I. G., Faskhanov, R. S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Antigens, CD19 - metabolism Bacterial Proteins - metabolism Biomedical and Life Sciences Biomedicine CD3 Complex - metabolism CD4 Antigens - metabolism CD8 Antigens - metabolism Cell Biology Fc receptors GPI-Linked Proteins - metabolism Host-Pathogen Interactions Humans Internal Medicine Laboratory Medicine Lymphocytes Lymphocytes - metabolism Lymphocytes - microbiology Pathology Peptide Hydrolases - metabolism Proteases Proteolysis Receptors, IgG - metabolism Staphylococcus aureus Staphylococcus aureus - enzymology
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Zusammenfassung:	The effects of Staphylococcus aureus proteolytic enzymes on surface receptors of human lymphocytes were studied. Proteolytic activity was detected in 35 supernatants of 45 S. aureus strains. aur and sspA genes were detected by PCR in 43 strains. Incubation of lymphocytes showed reduced expression of receptors labeled with anti-CD8, anti-CD4, and anti-CD16 antibodies and no changes in the receptors labeled with anti-CD3 and anti-CD19 antibodies in comparison with the control (incubation with sterile nutrient medium). S. aureus enzymes can trigger in vivo one of the mechanisms of early death of lymphocyte subpopulations expressing these receptors.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-013-2051-2