Protective effects of kolaviron and quercetin on cadmium-induced testicular damage and endocrine pathology in rats

Protective effects of kolaviron and quercetin on cadmium-induced testicular damage and endocrine pathology in rats

Summary This study evaluated the effects of kolaviron, a biflavonoid from Garcinia kola seed, and quercetin on cadmium‐induced reproductive toxicity in rats. Adult male rats were administered with either cadmium (15 mg kg−1) alone or in combination with kolaviron (200 mg kg−1) or quercetin (10 mg kg...

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Veröffentlicht in:Andrologia 2012-08, Vol.44 (4), p.273-284
Hauptverfasser: Farombi, E. O., Adedara, I. A., Akinrinde, S. A., Ojo, O. O., Eboh, A. S.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Cadmium
Cadmium - toxicity
Endocrine Glands - drug effects
Endocrine Glands - pathology
Flavonoids - pharmacology
Garcinia kola
kolaviron
Male
oxidative stress
quercetin
Quercetin - pharmacology
Rats
Rats, Wistar
testes
Testis - drug effects
Testis - pathology
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Beschreibung
Zusammenfassung:Summary This study evaluated the effects of kolaviron, a biflavonoid from Garcinia kola seed, and quercetin on cadmium‐induced reproductive toxicity in rats. Adult male rats were administered with either cadmium (15 mg kg−1) alone or in combination with kolaviron (200 mg kg−1) or quercetin (10 mg kg−1) daily for 5 days. Cadmium‐treated rats showed (P 
ISSN:0303-4569
1439-0272
DOI:10.1111/j.1439-0272.2012.01279.x