Effects of Carnosine on Polyamine Levels in Red Blood Cells of Patients with Hypertonic Discirculatory Encephalopathy

The levels of polyamines (putrescine, spermine, spermidine) in erythrocytes from patients with hypertonic discirculatory encephalopathy are reduced (by 37, 45, and 50%, respectively) in comparison with the corresponding parameters in the control group. Addition of carnosine to the treatment protocol...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2012-12, Vol.154 (2), p.210-212
Hauptverfasser:	Makletsova, M. G., Fedorova, T. N., Maksimova, M. Yu, Boldyrev, A. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Biomedical and Life Sciences Biomedicine Biophysics and Biochemistry Brain Ischemia - drug therapy Brain Ischemia - metabolism Care and treatment Carnosine - pharmacology Carnosine - therapeutic use Cell Biology Cerebrovascular Disorders - metabolism Encephalopathy Erythrocytes - drug effects Erythrocytes - metabolism Female Humans Internal Medicine Ischemia Laboratory Medicine Male Methyl aspartate Middle Aged Pathology Physiological aspects Polyamines Polyamines - metabolism Putrescine - metabolism Spermine - metabolism
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Zusammenfassung:	The levels of polyamines (putrescine, spermine, spermidine) in erythrocytes from patients with hypertonic discirculatory encephalopathy are reduced (by 37, 45, and 50%, respectively) in comparison with the corresponding parameters in the control group. Addition of carnosine to the treatment protocol for chronic brain ischemia normalized the content of putrescine and spermine. The mechanisms of carnosine influence on polyamine metabolism are discussed: trapping of acrolein, end-product of polyamine oxidation, and compensation of NMDAreceptor excitotoxicity.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-012-1914-2