Impact of Antiviral Preventive Strategies on the Incidence and Outcomes of Cytomegalovirus Disease in Solid Organ Transplant Recipients

Impact of Antiviral Preventive Strategies on the Incidence and Outcomes of Cytomegalovirus Disease in Solid Organ Transplant Recipients

We assessed the impact of antiviral prophylaxis and preemptive therapy on the incidence and outcomes of cytomegalovirus (CMV) disease in a nationwide prospective cohort of solid organ transplant recipients. Risk factors associated with CMV disease and graft failure‐free survival were analyzed using...

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Veröffentlicht in:American journal of transplantation 2013-09, Vol.13 (9), p.2402-2410
Hauptverfasser: Manuel, O., Kralidis, G., Mueller, N. J., Hirsch, H. H., Garzoni, C., van Delden, C., Berger, C., Boggian, K., Cusini, A., Koller, M. T., Weisser, M., Pascual, M., Meylan, P. R.
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Aged
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiviral agents
Antiviral Agents - therapeutic use
Antiviral prophylaxis
Biological and medical sciences
Cytomegalovirus
Cytomegalovirus Infections - epidemiology
Cytomegalovirus Infections - prevention & control
Disease prevention
Female
Ganciclovir - analogs & derivatives
Ganciclovir - therapeutic use
graft loss
Graft Survival
Herpesviridae
Humans
Incidence
indirect effects
Male
Medical sciences
Middle Aged
Organ Transplantation
Pharmacology. Drug treatments
preemptive therapy
Prevention and actions
Prospective Studies
Public health. Hygiene
Public health. Hygiene-occupational medicine
Risk Factors
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Transplants & implants
Valganciclovir
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Zusammenfassung:We assessed the impact of antiviral prophylaxis and preemptive therapy on the incidence and outcomes of cytomegalovirus (CMV) disease in a nationwide prospective cohort of solid organ transplant recipients. Risk factors associated with CMV disease and graft failure‐free survival were analyzed using Cox regression models. One thousand two hundred thirty‐nine patients transplanted from May 2008 until March 2011 were included; 466 (38%) patients received CMV prophylaxis and 522 (42%) patients were managed preemptively. Overall incidence of CMV disease was 6.05% and was linked to CMV serostatus (D+/R− vs. R+, hazard ratio [HR] 5.36 [95% CI 3.14–9.14], p 
ISSN:1600-6135
1600-6143
DOI:10.1111/ajt.12388