Bayesian Quantile Regression for Censored Data

In this paper we propose a semiparametric quantile regression model for censored survival data. Quantile regression permits covariates to affect survival differently at different stages in the follow-up period, thus providing a comprehensive study of the survival distribution. We take a semiparametr...

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Veröffentlicht in:Biometrics 2013-09, Vol.69 (3), p.651-660
Hauptverfasser: Reich, Brian J., Smith, Luke B.
Format: Artikel
Sprache:eng
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Zusammenfassung:In this paper we propose a semiparametric quantile regression model for censored survival data. Quantile regression permits covariates to affect survival differently at different stages in the follow-up period, thus providing a comprehensive study of the survival distribution. We take a semiparametric approach, representing the quantile process as a linear combination of basis functions. The basis functions are chosen so that the prior for the quantile process is centered on a simple location-scale model, but flexible enough to accommodate a wide range of quantile processes. We show in a simulation study that this approach is competitive with existing methods. The method is illustrated using data from a drug treatment study, where we find that the Bayesian model often gives smaller measures of uncertainty than its competitors, and thus identifies more significant effects.
ISSN:0006-341X
1541-0420
DOI:10.1111/biom.12053