Use of In Situ Atomic Force Microscopy to Follow Phase Changes at Crystal Surfaces in Real Time

Use of In Situ Atomic Force Microscopy to Follow Phase Changes at Crystal Surfaces in Real Time

AFM of cocrystals: Atomic force microscopy can be used to observe phase changes at crystal surfaces where the transformation is accompanied by a change in the spacing between layers of molecules (see picture). The conversion of a metastable polymorph of the caffeine–glutaric acid cocrystal into the...

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Veröffentlicht in:Angewandte Chemie International Edition 2013-09, Vol.52 (40), p.10541-10544
Hauptverfasser: Thakuria, Ranjit, Eddleston, Mark D., Chow, Ernest H. H., Lloyd, Gareth O., Aldous, Barry J., Krzyzaniak, Joseph F., Bond, Andrew D., Jones, William
Format: Artikel
Sprache:eng
Schlagworte:
atomic force microscopy
Caffeine - chemistry
cocrystals
Crystallization
Glutarates - chemistry
Microscopy, Atomic Force - methods
Phase Transition
phase transitions
polymorphism
surface analysis
Surface Properties
Thermodynamics
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Beschreibung
Zusammenfassung:AFM of cocrystals: Atomic force microscopy can be used to observe phase changes at crystal surfaces where the transformation is accompanied by a change in the spacing between layers of molecules (see picture). The conversion of a metastable polymorph of the caffeine–glutaric acid cocrystal into the thermodynamically stable form was analyzed continuously in situ using intermittent‐contact‐mode atomic force microscopy.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201302532