Selective exposure and analysis of the sheep tracheal lobe as a model for toxicological studies of respirable particles

A conscious sheep model, recently developed to study sequentially the bronchoalveolar milieu, was further refined to use in the rapid in vivo assessment of the biological effects of respirable particles. In this model, the anatomically isolated tracheal lobe was selectively exposed to either 100 ml...

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Veröffentlicht in:	Environ. Res.; (United States) 1985-04, Vol.36 (2), p.389-404
Hauptverfasser:	Bégin, R., Massé, S., Rola-Pleszczynski, M., Drapeau, G., Dalle, D.
Format:	Artikel
Sprache:	eng
Schlagworte:	560305 - Chemicals Metabolism & Toxicology- Vertebrates- (-1987) Air Pollutants - toxicity ANIMAL CELLS ANIMALS ASBESTOS Asbestos - toxicity Asbestos, Serpentine Biological and medical sciences BIOLOGICAL MATERIALS BLOOD BLOOD CELLS BODY FLUIDS Chemical and industrial products toxicology. Toxic occupational diseases CONNECTIVE TISSUE CELLS DATA DOMESTIC ANIMALS DYNAMIC FUNCTION STUDIES ELASTOMERS ENZYME ACTIVITY ENZYMES EXPERIMENTAL DATA INFORMATION Inorganic dusts (pneumoconiosises) and organic dusts (byssinosis etc.) LATEX Latex - toxicity LAVAGE LEUKOCYTES Lung - pathology MACROPHAGES Male MAMMALS MATERIALS Medical sciences Models, Biological NEUTROPHILS NUMERICAL DATA ORGANIC COMPOUNDS ORGANIC POLYMERS OXIDOREDUCTASES PARTICLES PARTICULATES PATHOLOGICAL CHANGES PHAGOCYTES POLYMERS Pulmonary Alveoli - analysis RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RESPIRATORY SYSTEM RUBBERS RUMINANTS SHEEP SOMATIC CELLS Therapeutic Irrigation TOXICITY Toxicology TRACHEA Trachea - drug effects VERTEBRATES
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