Cytotoxic Rocaglamide Derivatives from Aglaia duppereana

Cytotoxic Rocaglamide Derivatives from Aglaia duppereana

Phytochemical investigation of Aglaia duppereana flowers led to the isolation of a new rocaglamide derivative and twelve known congeners. The structure of the new compound was unambiguously elucidated by spectroscopic techniques (1D- and 2D-NMR, HRESIMS). The isolated compounds exhibited a potent cy...

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Veröffentlicht in:Zeitschrift für Naturforschung C. A journal of biosciences 2013-08, Vol.68 (7), p.269-274
Hauptverfasser: El-Neketi, Mona, Ebrahim, Weaam, Duong, Ngoc Tu, Gedara, Sahar, Badria, Farid, Saad, Hassan-Elrady A., Müller, Werner E. G., Proksch, Peter
Format: Artikel
Sprache:eng
Schlagworte:
Aglaia - chemistry
Aglaia duppereana
Animals
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - pharmacology
Benzofurans - chemistry
Benzofurans - pharmacology
Cell Line, Tumor
Cytotoxicity
Drug Screening Assays, Antitumor
Magnetic Resonance Spectroscopy
Mice
Molecular Structure
Rocaglamide
Spectrometry, Mass, Electrospray Ionization
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Zusammenfassung:Phytochemical investigation of Aglaia duppereana flowers led to the isolation of a new rocaglamide derivative and twelve known congeners. The structure of the new compound was unambiguously elucidated by spectroscopic techniques (1D- and 2D-NMR, HRESIMS). The isolated compounds exhibited a potent cytotoxic activity against mouse lymphoma (L5178Y) cells with EC50 values ranging from 5.1 to 54.8 nM
ISSN:0939-5075
1865-7125
DOI:10.1515/znc-2013-7-803