Oral Corticosteroids and Onset of Cardiomyopathy in Duchenne Muscular Dystrophy

Objective To estimate the age when cardiomyopathy develops in boys with Duchenne muscular dystrophy (DMD) and to analyze the effect of corticosteroid treatment on the age of cardiomyopathy onset. Study design We identified a population-based sample of 462 boys with DMD, born between 1982 and 2005, i...

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Veröffentlicht in:	The Journal of pediatrics 2013-10, Vol.163 (4), p.1080-1084.e1
Hauptverfasser:	Barber, Brent J., MD, Andrews, Jennifer G., MBA, Lu, Zhenqiang, PhD, West, Nancy A., PhD, Meaney, F. John, PhD, Price, Elinora T., BA, Gray, Ashley, BS, Sheehan, Daniel W., MD, Pandya, Shree, PT, DPT, MS, Yang, Michele, MD, Cunniff, Christopher, MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Adolescent adrenal cortex hormones Adrenal Cortex Hormones - administration & dosage Adrenal Cortex Hormones - therapeutic use Age of Onset boys Cardiomyopathies - complications Cardiomyopathies - drug therapy Cardiomyopathies - epidemiology cardiomyopathy Child Child, Preschool correlation Echocardiography Humans Male monitoring muscular dystrophy Muscular Dystrophy, Duchenne - complications Muscular Dystrophy, Duchenne - drug therapy Pediatrics probability Regression Analysis Time Factors Treatment Outcome
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Zusammenfassung:	Objective To estimate the age when cardiomyopathy develops in boys with Duchenne muscular dystrophy (DMD) and to analyze the effect of corticosteroid treatment on the age of cardiomyopathy onset. Study design We identified a population-based sample of 462 boys with DMD, born between 1982 and 2005, in 5 surveillance sites in the US. Echocardiographic and corticosteroid treatment data were collected. Cardiomyopathy was defined by a reduced fractional shortening (
ISSN:	0022-3476 1097-6833
DOI:	10.1016/j.jpeds.2013.05.060