The effects of long-term dietary administration of the rubber accelerator, N-oxydiethylene thiocarbamyl- N-oxydiethylene sulfenamide, to rats

Continuous administration of diets containing 0, 20, 60, 200, or 600 ppm of N-oxydiethylene thiocarbamyl- N-oxydiethylene sulfenamide to groups of male and female Sprague-Dawley rats (60/sex/group) for over 2 years resulted in oncogenic and toxic effects which generally were limited to the high-dose (600 ppm) group. The most significant findings of this study were in the urinary system of the high-dose males and females. Postmortem examinations revealed a compound-related increase in both benign and malignant urothelial tumors in these animals but not in animals at lower doses. These observations in the high-dose animals paralleled an increase in kidney weights and non-neoplastic urinary tract abnormalities. In both sexes of the high-dose group, body weights were significantly lower and the incidence of rales was significantly higher than those of control animals throughout the course of the study. While some statistically significant changes in hematology, chemical chemistry, and urinalysis values were noted, no compound-related effect on these parameters was evident.