Can soman cause delayed neuropathy?
It was reported that when adult hens were protected against acute cholinergic effects, a high dose of soman caused 55% inhibition of neuropathy target esterase (NTE) in the brain soon after dosing, and it was proposed that a dose of about 120 x LD50, if it could be tolerated with the aid of improved...
Gespeichert in:
| Veröffentlicht in: | Fundamental and applied toxicology 1985-12, Vol.5 (6), p.S180-S181 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | S181 |
|---|---|
| container_issue | 6 |
| container_start_page | S180 |
| container_title | Fundamental and applied toxicology |
| container_volume | 5 |
| creator | Johnson, Martin K. Willems, Jan L. De Bisschop, Herbert C. Read, David J. Benschop, Hendrik P. |
| description | It was reported that when adult hens were protected against acute cholinergic effects, a high dose of soman caused 55% inhibition of neuropathy target esterase (NTE) in the brain soon after dosing, and it was proposed that a dose of about 120 x LD50, if it could be tolerated with the aid of improved prophylaxis and therapy, would cause delayed neuropathy. Subsequently, Willems et al. found that one out of six birds treated with 1.5 mg/kg soman survived and developed an apparently typical severe delayed neuropathy, but with first signs seen only 13 days after dosing. |
| doi_str_mv | 10.1016/0272-0590(85)90128-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_14369935</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>0272059085901289</els_id><sourcerecordid>14369935</sourcerecordid><originalsourceid>FETCH-LOGICAL-c320t-5d2e711c8eecb76579453fec5d4fd445a7e1371fb197b4034806cd8089ec94743</originalsourceid><addsrcrecordid>eNp9UMtKAzEUDaLUWv0DhYIguhi9eU2SjSLFFxTc6Dpkkjs4Mo-azAj9e6e2uHRzz-I8LucQckrhmgLNb4AploE0cKnllQHKdGb2yJSCkVmuOdsn0z_JITlK6ROAUilgQiYCDNNaTcn5wrXz1DXj9W5IOA9YuzWGeYtD7Fau_1jfHZOD0tUJT3Y4I--PD2-L52z5-vSyuF9mnjPoMxkYKkq9RvSFyqUyQvISvQyiDEJIp5ByRcuCGlUI4EJD7oMGbdAboQSfkYtt7ip2XwOm3jZV8ljXrsVuSJYKnhvD5SgUW6GPXUoRS7uKVePi2lKwm23sprjdFLda2t9trBltZ7v8oWgw_Jl2Y4z87ZbHseR3hdEmX2HrMVQRfW9DV_3_4AfsWnDT</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>14369935</pqid></control><display><type>article</type><title>Can soman cause delayed neuropathy?</title><source>MEDLINE</source><source>Oxford University Press Journals Digital Archive Legacy</source><source>Alma/SFX Local Collection</source><creator>Johnson, Martin K. ; Willems, Jan L. ; De Bisschop, Herbert C. ; Read, David J. ; Benschop, Hendrik P.</creator><creatorcontrib>Johnson, Martin K. ; Willems, Jan L. ; De Bisschop, Herbert C. ; Read, David J. ; Benschop, Hendrik P.</creatorcontrib><description>It was reported that when adult hens were protected against acute cholinergic effects, a high dose of soman caused 55% inhibition of neuropathy target esterase (NTE) in the brain soon after dosing, and it was proposed that a dose of about 120 x LD50, if it could be tolerated with the aid of improved prophylaxis and therapy, would cause delayed neuropathy. Subsequently, Willems et al. found that one out of six birds treated with 1.5 mg/kg soman survived and developed an apparently typical severe delayed neuropathy, but with first signs seen only 13 days after dosing.</description><identifier>ISSN: 0272-0590</identifier><identifier>EISSN: 1095-6832</identifier><identifier>DOI: 10.1016/0272-0590(85)90128-9</identifier><identifier>PMID: 4092887</identifier><language>eng</language><publisher>United States: Elsevier Science (USA)</publisher><subject>Animals ; Chickens ; Esterases - blood ; Isoflurophate - toxicity ; Nervous System Diseases - chemically induced ; Soman - toxicity ; Stereoisomerism</subject><ispartof>Fundamental and applied toxicology, 1985-12, Vol.5 (6), p.S180-S181</ispartof><rights>1985</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c320t-5d2e711c8eecb76579453fec5d4fd445a7e1371fb197b4034806cd8089ec94743</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4092887$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Johnson, Martin K.</creatorcontrib><creatorcontrib>Willems, Jan L.</creatorcontrib><creatorcontrib>De Bisschop, Herbert C.</creatorcontrib><creatorcontrib>Read, David J.</creatorcontrib><creatorcontrib>Benschop, Hendrik P.</creatorcontrib><title>Can soman cause delayed neuropathy?</title><title>Fundamental and applied toxicology</title><addtitle>Fundam Appl Toxicol</addtitle><description>It was reported that when adult hens were protected against acute cholinergic effects, a high dose of soman caused 55% inhibition of neuropathy target esterase (NTE) in the brain soon after dosing, and it was proposed that a dose of about 120 x LD50, if it could be tolerated with the aid of improved prophylaxis and therapy, would cause delayed neuropathy. Subsequently, Willems et al. found that one out of six birds treated with 1.5 mg/kg soman survived and developed an apparently typical severe delayed neuropathy, but with first signs seen only 13 days after dosing.</description><subject>Animals</subject><subject>Chickens</subject><subject>Esterases - blood</subject><subject>Isoflurophate - toxicity</subject><subject>Nervous System Diseases - chemically induced</subject><subject>Soman - toxicity</subject><subject>Stereoisomerism</subject><issn>0272-0590</issn><issn>1095-6832</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UMtKAzEUDaLUWv0DhYIguhi9eU2SjSLFFxTc6Dpkkjs4Mo-azAj9e6e2uHRzz-I8LucQckrhmgLNb4AploE0cKnllQHKdGb2yJSCkVmuOdsn0z_JITlK6ROAUilgQiYCDNNaTcn5wrXz1DXj9W5IOA9YuzWGeYtD7Fau_1jfHZOD0tUJT3Y4I--PD2-L52z5-vSyuF9mnjPoMxkYKkq9RvSFyqUyQvISvQyiDEJIp5ByRcuCGlUI4EJD7oMGbdAboQSfkYtt7ip2XwOm3jZV8ljXrsVuSJYKnhvD5SgUW6GPXUoRS7uKVePi2lKwm23sprjdFLda2t9trBltZ7v8oWgw_Jl2Y4z87ZbHseR3hdEmX2HrMVQRfW9DV_3_4AfsWnDT</recordid><startdate>19851201</startdate><enddate>19851201</enddate><creator>Johnson, Martin K.</creator><creator>Willems, Jan L.</creator><creator>De Bisschop, Herbert C.</creator><creator>Read, David J.</creator><creator>Benschop, Hendrik P.</creator><general>Elsevier Science (USA)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>19851201</creationdate><title>Can soman cause delayed neuropathy?</title><author>Johnson, Martin K. ; Willems, Jan L. ; De Bisschop, Herbert C. ; Read, David J. ; Benschop, Hendrik P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c320t-5d2e711c8eecb76579453fec5d4fd445a7e1371fb197b4034806cd8089ec94743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Animals</topic><topic>Chickens</topic><topic>Esterases - blood</topic><topic>Isoflurophate - toxicity</topic><topic>Nervous System Diseases - chemically induced</topic><topic>Soman - toxicity</topic><topic>Stereoisomerism</topic><toplevel>online_resources</toplevel><creatorcontrib>Johnson, Martin K.</creatorcontrib><creatorcontrib>Willems, Jan L.</creatorcontrib><creatorcontrib>De Bisschop, Herbert C.</creatorcontrib><creatorcontrib>Read, David J.</creatorcontrib><creatorcontrib>Benschop, Hendrik P.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Fundamental and applied toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Johnson, Martin K.</au><au>Willems, Jan L.</au><au>De Bisschop, Herbert C.</au><au>Read, David J.</au><au>Benschop, Hendrik P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Can soman cause delayed neuropathy?</atitle><jtitle>Fundamental and applied toxicology</jtitle><addtitle>Fundam Appl Toxicol</addtitle><date>1985-12-01</date><risdate>1985</risdate><volume>5</volume><issue>6</issue><spage>S180</spage><epage>S181</epage><pages>S180-S181</pages><issn>0272-0590</issn><eissn>1095-6832</eissn><abstract>It was reported that when adult hens were protected against acute cholinergic effects, a high dose of soman caused 55% inhibition of neuropathy target esterase (NTE) in the brain soon after dosing, and it was proposed that a dose of about 120 x LD50, if it could be tolerated with the aid of improved prophylaxis and therapy, would cause delayed neuropathy. Subsequently, Willems et al. found that one out of six birds treated with 1.5 mg/kg soman survived and developed an apparently typical severe delayed neuropathy, but with first signs seen only 13 days after dosing.</abstract><cop>United States</cop><pub>Elsevier Science (USA)</pub><pmid>4092887</pmid><doi>10.1016/0272-0590(85)90128-9</doi></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0272-0590 |
| ispartof | Fundamental and applied toxicology, 1985-12, Vol.5 (6), p.S180-S181 |
| issn | 0272-0590 1095-6832 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_14369935 |
| source | MEDLINE; Oxford University Press Journals Digital Archive Legacy; Alma/SFX Local Collection |
| subjects | Animals Chickens Esterases - blood Isoflurophate - toxicity Nervous System Diseases - chemically induced Soman - toxicity Stereoisomerism |
| title | Can soman cause delayed neuropathy? |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-21T11%3A48%3A16IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Can%20soman%20cause%20delayed%20neuropathy?&rft.jtitle=Fundamental%20and%20applied%20toxicology&rft.au=Johnson,%20Martin%20K.&rft.date=1985-12-01&rft.volume=5&rft.issue=6&rft.spage=S180&rft.epage=S181&rft.pages=S180-S181&rft.issn=0272-0590&rft.eissn=1095-6832&rft_id=info:doi/10.1016/0272-0590(85)90128-9&rft_dat=%3Cproquest_cross%3E14369935%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=14369935&rft_id=info:pmid/4092887&rft_els_id=0272059085901289&rfr_iscdi=true |