Can soman cause delayed neuropathy?

It was reported that when adult hens were protected against acute cholinergic effects, a high dose of soman caused 55% inhibition of neuropathy target esterase (NTE) in the brain soon after dosing, and it was proposed that a dose of about 120 x LD50, if it could be tolerated with the aid of improved...

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Veröffentlicht in:Fundamental and applied toxicology 1985-12, Vol.5 (6), p.S180-S181
Hauptverfasser: Johnson, Martin K., Willems, Jan L., De Bisschop, Herbert C., Read, David J., Benschop, Hendrik P.
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Sprache:eng
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Zusammenfassung:It was reported that when adult hens were protected against acute cholinergic effects, a high dose of soman caused 55% inhibition of neuropathy target esterase (NTE) in the brain soon after dosing, and it was proposed that a dose of about 120 x LD50, if it could be tolerated with the aid of improved prophylaxis and therapy, would cause delayed neuropathy. Subsequently, Willems et al. found that one out of six birds treated with 1.5 mg/kg soman survived and developed an apparently typical severe delayed neuropathy, but with first signs seen only 13 days after dosing.
ISSN:0272-0590
1095-6832
DOI:10.1016/0272-0590(85)90128-9