Computer-linked HPLC system for feedback control of fermentation substrates

Computer-linked HPLC system for feedback control of fermentation substrates

A data acquisition/control microcomputer system was interfaced to a commercial HPLC data transmission module. Control of substrate (ethanol) levels for four 7.5 L fermenters containing 100 g/L wet weight of the yeast Candida norvegensis was accomplished by employing intermittent, automated HPLC moni...

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Veröffentlicht in:Biotechnology letters 1986-05, Vol.8 (5), p.311-314
Hauptverfasser: MATHERS, J. J, DINWOODIE, R. C, TALAROVICH, M, MEHNERT, D. W
Format: Artikel
Sprache:eng
Schlagworte:
Biological and medical sciences
Biotechnology
Candida norvegenesis
computer applications
fermentation
Fundamental and applied biological sciences. Psychology
Methods. Procedures. Technologies
Microbial engineering. Fermentation and microbial culture technology
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Zusammenfassung:A data acquisition/control microcomputer system was interfaced to a commercial HPLC data transmission module. Control of substrate (ethanol) levels for four 7.5 L fermenters containing 100 g/L wet weight of the yeast Candida norvegensis was accomplished by employing intermittent, automated HPLC monitoring and a BASIC-encoded proportional integral policy for controlling substrate feed rates. Ethanol levels were maintained at 0.25, 0.50, 0.75, and 1.00% w/v.
ISSN:0141-5492
1573-6776
DOI:10.1007/BF01040855