Hemoglobin SO-Arab and α-Thalassemia Diagnosed in an Adult: A Case-based Review of the Hemoglobinopathies

Hemoglobin SO-Arab is a rare sickling disorder with a clinical course similar to that of hemoglobin SS. Hemoglobin C-Harlem is another rare condition that produces sickling disorders in affected individuals with a disease course and electrophoretic findings similar to that of hemoglobin SO-Arab. The...

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Veröffentlicht in:	The American journal of the medical sciences 2013-10, Vol.346 (4), p.325-327
Hauptverfasser:	Zacharia, George, MD, Maronge, Genevieve F., MD, Boulmay, Brian C., MD, Brazda, Frederick W., MD, Lopez, Fred A., MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult African Americans alpha-Thalassemia - diagnosis alpha-Thalassemia - genetics alpha-Thalassemia - metabolism Anemia, Sickle Cell - diagnosis Anemia, Sickle Cell - genetics Anemia, Sickle Cell - metabolism Chromatography, High Pressure Liquid - methods DNA Electrophoresis Electrophoresis - methods Genetic Techniques Hemoglobin Hemoglobin, Sickle - analysis Hemoglobinopathies Hemoglobins, Abnormal - analysis Heterozygote Humans Internal Medicine Louisiana Male Sequence analysis Sickle Thalassemia
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Zusammenfassung:	Hemoglobin SO-Arab is a rare sickling disorder with a clinical course similar to that of hemoglobin SS. Hemoglobin C-Harlem is another rare condition that produces sickling disorders in affected individuals with a disease course and electrophoretic findings similar to that of hemoglobin SO-Arab. The authors report the case of a 38-year-old African American man with hemoglobin SO-Arab and the challenges that may arise in working up a rare hemoglobinopathy.
ISSN:	0002-9629 1538-2990
DOI:	10.1097/MAJ.0b013e318275625b