Barley grains for the production of endotoxin-free growth factors

Barley grains for the production of endotoxin-free growth factors

Highlights • Plant platforms are emerging as a new and promising option for the production of recombinant proteins. • Recombinant proteins can introduce endotoxin when added to a cell culture. • Producing recombinant proteins in barley seed is a robust and well-established process. • Barley seed is...

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Veröffentlicht in:Trends in biotechnology (Regular ed.) 2013-10, Vol.31 (10), p.572-580
Hauptverfasser: Magnusdottir, Audur, Vidarsson, Hilmar, Björnsson, Jon Mar, Örvar, Björn Larus
Format: Artikel
Sprache:eng
Schlagworte:
Aqueous solutions
Bacteria
Barley
Biological and medical sciences
Biological products
Biomedical materials
bioprocessing
Biotechnology
Cell culture
E coli
Endotoxins
FDA approval
Fundamental and applied biological sciences. Psychology
genes
Grain
Growth factors
Hordeum - genetics
Hordeum - growth & development
Hordeum - metabolism
hosts
humans
In vitro fertilization
Intercellular Signaling Peptides and Proteins - biosynthesis
Intercellular Signaling Peptides and Proteins - genetics
Internal Medicine
Medicine
pathogens
plant development
Plants, Genetically Modified - genetics
Plants, Genetically Modified - growth & development
Plants, Genetically Modified - metabolism
production costs
Proteins
recombinant proteins
Recombinant Proteins - biosynthesis
Recombinant Proteins - genetics
Rodents
Stem cells
Studies
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Beschreibung
Zusammenfassung:Highlights • Plant platforms are emerging as a new and promising option for the production of recombinant proteins. • Recombinant proteins can introduce endotoxin when added to a cell culture. • Producing recombinant proteins in barley seed is a robust and well-established process. • Barley seed is an ample platform for producing high quality, endotoxin-free proteins for use in medical research.
ISSN:0167-7799
1879-3096
DOI:10.1016/j.tibtech.2013.06.002