Mechanisms of NOD-like Receptor-Associated Inflammasome Activation

A major function of a subfamily of NLR (nucleotide-binding domain, leucine-rich repeat containing, or NOD-like receptor) proteins is in inflammasome activation, which has been implicated in a multitude of disease models and human diseases. This work will highlight key progress in understanding the m...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2013-09, Vol.39 (3), p.432-441
Hauptverfasser:	Wen, Haitao, Miao, Edward A., Ting, Jenny P.-Y.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - immunology Adaptor Proteins, Signal Transducing - metabolism Animals Apoptosis Regulatory Proteins - immunology Apoptosis Regulatory Proteins - metabolism Calcium-Binding Proteins - immunology Calcium-Binding Proteins - metabolism CARD Signaling Adaptor Proteins - immunology CARD Signaling Adaptor Proteins - metabolism Carrier Proteins - immunology Carrier Proteins - metabolism Caspase 1 - metabolism Enzyme Activation Homeostasis Humans Inflammasomes - immunology Mice Mitochondria Mitochondrial DNA Mortality Neuronal Apoptosis-Inhibitory Protein - immunology Neuronal Apoptosis-Inhibitory Protein - metabolism NLR Family, Pyrin Domain-Containing 3 Protein Proteins Receptors, Cytoplasmic and Nuclear - immunology Signal Transduction Studies
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Beschreibung
Zusammenfassung:	A major function of a subfamily of NLR (nucleotide-binding domain, leucine-rich repeat containing, or NOD-like receptor) proteins is in inflammasome activation, which has been implicated in a multitude of disease models and human diseases. This work will highlight key progress in understanding the mechanisms that activate the best-studied NLRs (NLRP3, NLRC4, NAIP, and NLRP1) and in uncovering inflammasome NLRs.
ISSN:	1074-7613 1097-4180
DOI:	10.1016/j.immuni.2013.08.037