Mudulation of acetylcholine release from rat striatal slices by the GABA/benzodiazepine receptor complex

Mudulation of acetylcholine release from rat striatal slices by the GABA/benzodiazepine receptor complex

GABA, THIP and muscimol enhance spontaneous and inhibit electrically induced release of tritium labelled compounds from rat striatal slices which have been pre-labelled with super(3)H-choline. Muscimol can inhibit electrically induced release of tritiated material by approximately 75% with half maxi...

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Veröffentlicht in:Life sciences (1973) 1985-01, Vol.36 (5), p.417-426
Hauptverfasser: Supavilai, P, Karobath, M
Format: Artikel
Sprache:eng
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Zusammenfassung:GABA, THIP and muscimol enhance spontaneous and inhibit electrically induced release of tritium labelled compounds from rat striatal slices which have been pre-labelled with super(3)H-choline. Muscimol can inhibit electrically induced release of tritiated material by approximately 75% with half maximal effects at 2 mu M. The results demonstrate that a GABA/benzodiazepine receptor complex can modulate acetylcholine release from rat striatal slices in vitro.
ISSN:0024-3205