The use of an engineered single chain variable fragment in a localized surface plasmon resonance method for analysis of the C-reactive protein

The use of an engineered single chain variable fragment in a localized surface plasmon resonance method for analysis of the C-reactive protein

A gold nanorod (GNR) based LSPR sensor has been developed for label-free detection of C-reactive protein (CRP). The sensor utilizes a single chain variable fragment (scFv) as a receptor to bind CRP. The results of this effort show that CRP in human serum can be quantitatively detected at lower than...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2013-10, Vol.49 (82), p.9497-9499
Hauptverfasser: Byun, Ju-Young, Shin, Yong-Beom, Li, Taihua, Park, Jin-Ho, Kim, Dong-Myung, Choi, Dong-Hwan, Kim, Min-Gon
Format: Artikel
Sprache:eng
Schlagworte:
Blood Chemical Analysis - methods
C-Reactive Protein - chemistry
C-Reactive Protein - metabolism
Gold - chemistry
Humans
Limit of Detection
Nanotubes - chemistry
Single-Chain Antibodies - chemistry
Single-Chain Antibodies - metabolism
Surface Plasmon Resonance
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Zusammenfassung:A gold nanorod (GNR) based LSPR sensor has been developed for label-free detection of C-reactive protein (CRP). The sensor utilizes a single chain variable fragment (scFv) as a receptor to bind CRP. The results of this effort show that CRP in human serum can be quantitatively detected at lower than 1 ng mL(-1).
ISSN:1359-7345
1364-548X
DOI:10.1039/c3cc45046e