Naphthyridinomycin Biosynthesis Revealing the Use of Leader Peptide to Guide Nonribosomal Peptide Assembly

Analysis of naphthyridinomycin gene cluster revealed that this antibiotic is generated by nonribosomal peptide synthetase (NRPS) machinery. However, four modules encoded by two genes do not correspond with the structural units in the final product. Genetic and biochemical characterization of the gen...

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Veröffentlicht in:	Organic letters 2013-07, Vol.15 (14), p.3674-3677
Hauptverfasser:	Pu, Jin-Yue, Peng, Chao, Tang, Man-Cheng, Zhang, Yue, Guo, Jian-Ping, Song, Li-Qiang, Hua, Qiang, Tang, Gong-Li
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaloids - chemistry Alkaloids - metabolism Amino Acid Sequence Molecular Structure Multigene Family Naphthyridines - chemistry Naphthyridines - metabolism Peptide Synthases - chemistry Peptide Synthases - genetics Peptide Synthases - metabolism Peptides - chemistry Peptides - genetics Peptides - metabolism Tetrahydroisoquinolines - chemistry Tetrahydroisoquinolines - metabolism
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Beschreibung
Zusammenfassung:	Analysis of naphthyridinomycin gene cluster revealed that this antibiotic is generated by nonribosomal peptide synthetase (NRPS) machinery. However, four modules encoded by two genes do not correspond with the structural units in the final product. Genetic and biochemical characterization of the gene cluster suggested that the leader peptide mechanism for the NRPS assembly line was involved in biosynthesis of this tetrahydroisoquinoline alkaloid.
ISSN:	1523-7060 1523-7052
DOI:	10.1021/ol401549y