A genome-wide association study identifies a genetic variant in the SIAH2 locus associated with hormonal receptor-positive breast cancer in Japanese

In Japan, breast cancer is the most common cancer among women and the second leading cause of cancer death among women worldwide. To identify genetic variants associated with the disease susceptibility, we performed a genome-wide association study (GWAS) using a total of 1086 Japanese female patient...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of human genetics 2012-12, Vol.57 (12), p.766-771
Hauptverfasser:	Elgazzar, Seham, Zembutsu, Hitoshi, Takahashi, Atsushi, Kubo, Michiaki, Aki, Fuminori, Hirata, Koichi, Takatsuka, Yuichi, Okazaki, Minoru, Ohsumi, Shozo, Yamakawa, Takashi, Sasa, Mitsunori, Katagiri, Toyomasa, Miki, Yoshio, Nakamura, Yusuke
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Asian Continental Ancestry Group - genetics Breast cancer Breast Neoplasms - genetics Breast Neoplasms - metabolism Carcinoma, Intraductal, Noninfiltrating - genetics Carcinoma, Intraductal, Noninfiltrating - metabolism Case-Control Studies Chromosome 3 Chromosomes, Human, Pair 3 - genetics Estrogens Female Fibroblast growth factor receptor 2 Genetic diversity Genetic Predisposition to Disease Genome-wide association studies Genome-Wide Association Study Genomes Genotype Humans Middle Aged Neoplasms, Hormone-Dependent - genetics Neoplasms, Hormone-Dependent - metabolism Nuclear Proteins - genetics Nuclear Proteins - metabolism Polymorphism, Single Nucleotide - genetics Receptor, Fibroblast Growth Factor, Type 2 - genetics Receptors, Estrogen - metabolism Risk Factors Single-nucleotide polymorphism Susceptibility Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	In Japan, breast cancer is the most common cancer among women and the second leading cause of cancer death among women worldwide. To identify genetic variants associated with the disease susceptibility, we performed a genome-wide association study (GWAS) using a total of 1086 Japanese female patients with hormonal receptor-positive (HRP) breast cancer and 1816 female controls. We selected 33 single-nucleotide polymorphisms (SNPs) with suggestive associations in GWAS (P-value of
ISSN:	1434-5161 1435-232X
DOI:	10.1038/jhg.2012.108