Sesterterpenes and 2H-Pyran-2-ones (=α-Pyrones) from the Mangrove-Derived Endophytic Fungus Fusarium proliferatum MA-84

Two new tricyclic sesterterpenes, fusaprolifins A and B (1 and 2), and three new 2H‐pyran‐2‐one derivatives, prolipyrones A – C (3–5), were isolated and characterized from Fusarium proliferatum MA‐84, an endophytic fungus obtained from the fresh tissue of the marine mangrove plant Bruguiera sexangula. In addition, two known sesterterpenes, terpestacin (6) and fusaproliferin (7), and one known 2H‐pyran‐2‐one derivative, gibepyrone D (8), were also identified. The structures of these compounds were elucidated by detailed spectroscopic analyses. Fusaprolifin A (1) showed moderate activity against brine shrimp (Artemia salina), with a lethality rate of 49.5% at 100 μg/ml, while fusaprolifin B (2) showed weak activity.