Antimicrobial and antioxidant activity evaluation of tetrazolo[1,5-a]pyrimidines: A simple diisopropylammonium trifluoroacetate mediated synthesis

Antimicrobial and antioxidant activity evaluation of tetrazolo[1,5-a]pyrimidines: A simple diisopropylammonium trifluoroacetate mediated synthesis

A simple, efficient and economic synthesis of tetrazolo [1,5-a]pyrimidine-6-carboxylates was accomplished by three-component reaction of beta -ketoesters with a mixture of aromatic aldehyde and 5-aminotetrazole using TFA:DIPEA (1 : 1) as the catalyst. The synthesized tetrazole compounds are evaluate...

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Veröffentlicht in:RSC advances 2012-01, Vol.2 (31), p.11657-11663
Hauptverfasser: Raju, Chandran, Madhaiyan, Kalaipriya, Uma, Ramakrishnan, Sridhar, Radhakrishnan, Ramakrishna, Seeram
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Aldehydes
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container_end_page 11663
container_issue 31
container_start_page 11657
container_title RSC advances
container_volume 2
creator Raju, Chandran
Madhaiyan, Kalaipriya
Uma, Ramakrishnan
Sridhar, Radhakrishnan
Ramakrishna, Seeram
description A simple, efficient and economic synthesis of tetrazolo [1,5-a]pyrimidine-6-carboxylates was accomplished by three-component reaction of beta -ketoesters with a mixture of aromatic aldehyde and 5-aminotetrazole using TFA:DIPEA (1 : 1) as the catalyst. The synthesized tetrazole compounds are evaluated for their antimicrobial and antioxidant activity.
doi_str_mv 10.1039/c2ra21330c
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title Antimicrobial and antioxidant activity evaluation of tetrazolo[1,5-a]pyrimidines: A simple diisopropylammonium trifluoroacetate mediated synthesis
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