Antimicrobial and antioxidant activity evaluation of tetrazolo[1,5-a]pyrimidines: A simple diisopropylammonium trifluoroacetate mediated synthesis

Antimicrobial and antioxidant activity evaluation of tetrazolo[1,5-a]pyrimidines: A simple diisopropylammonium trifluoroacetate mediated synthesis

A simple, efficient and economic synthesis of tetrazolo [1,5-a]pyrimidine-6-carboxylates was accomplished by three-component reaction of beta -ketoesters with a mixture of aromatic aldehyde and 5-aminotetrazole using TFA:DIPEA (1 : 1) as the catalyst. The synthesized tetrazole compounds are evaluate...

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Veröffentlicht in:RSC advances 2012-01, Vol.2 (31), p.11657-11663
Hauptverfasser: Raju, Chandran, Madhaiyan, Kalaipriya, Uma, Ramakrishnan, Sridhar, Radhakrishnan, Ramakrishna, Seeram
Format: Artikel
Sprache:eng
Schlagworte:
Aldehydes
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Zusammenfassung:A simple, efficient and economic synthesis of tetrazolo [1,5-a]pyrimidine-6-carboxylates was accomplished by three-component reaction of beta -ketoesters with a mixture of aromatic aldehyde and 5-aminotetrazole using TFA:DIPEA (1 : 1) as the catalyst. The synthesized tetrazole compounds are evaluated for their antimicrobial and antioxidant activity.
ISSN:2046-2069
2046-2069
DOI:10.1039/c2ra21330c