Biodegradable Polymer-Curcumin Conjugate Micelles Enhance the Loading and Delivery of Low-Potency Curcumin

Biodegradable Polymer-Curcumin Conjugate Micelles Enhance the Loading and Delivery of Low-Potency Curcumin

ABSTRACT Purpose To utilize a novel type of polymer-drug conjugate micelle to enhance the delivery of low-potency curcumin. Methods Multiple curcumin molecules were conjugated to poly(lactic acid) (PLA) via tris(hydroxymethyl)aminomethane (Tris) linker producing the hydrophobic drug-binding block; m...

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Veröffentlicht in:Pharmaceutical research 2012-12, Vol.29 (12), p.3512-3525
Hauptverfasser: Yang, Rulei, Zhang, Suai, Kong, Deling, Gao, Xuli, Zhao, Yanjun, Wang, Zheng
Format: Artikel
Sprache:eng
Schlagworte:
Antineoplastic Agents - administration & dosage
Antineoplastic Agents - pharmacokinetics
Antineoplastic Agents - pharmacology
Biochemistry
Biodegradable materials
Biological and medical sciences
Biomedical and Life Sciences
Biomedical Engineering and Bioengineering
Biomedicine
Biopolymers
Cell Survival - drug effects
Curcumin - administration & dosage
Curcumin - pharmacokinetics
Curcumin - pharmacology
Drug Carriers - chemistry
Drug delivery systems
General pharmacology
Hep G2 Cells
Humans
Medical Law
Medical sciences
Micelles
Neoplasms - drug therapy
Pharmaceutical sciences
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Pharmacology/Toxicology
Pharmacy
Polyesters - chemistry
Polyethylene Glycols - chemistry
Research Paper
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Zusammenfassung:ABSTRACT Purpose To utilize a novel type of polymer-drug conjugate micelle to enhance the delivery of low-potency curcumin. Methods Multiple curcumin molecules were conjugated to poly(lactic acid) (PLA) via tris(hydroxymethyl)aminomethane (Tris) linker producing the hydrophobic drug-binding block; methoxy-poly(ethylene glycol) (mPEG) was employed as the hydrophilic block. Micelles were characterized by size, loading capacity, stability, and critical micelle concentration (CMC). Human hepatocellular carcinoma (HepG2) cells were employed to assess cytotoxicity and intracellular targeting ability of micelles. Results mPEG-PLA-Tris-Cur micelles were within nanorange (
ISSN:0724-8741
1573-904X
DOI:10.1007/s11095-012-0848-8