Stress, anxiety, and dendritic spines: What are the connections?

Highlights ► Stress can produce a state of anxiety that if sustained can lead to mental illness. ► Stress also alters dendrites and spines in the hippocampus, mPFC, and amygdala. ► These structural changes may underlie adaptive and maladaptive anxiety responses.

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Bibliographische Detailangaben
Veröffentlicht in:	Neuroscience 2013-10, Vol.251, p.108-119
Hauptverfasser:	Leuner, B, Shors, T.J
Format:	Artikel
Sprache:	eng
Schlagworte:	amygdala Amygdala - physiopathology Animals Anxiety - physiopathology Brain - pathology Brain - physiopathology Dendritic Spines - pathology Dendritic Spines - physiology hippocampus Hippocampus - physiopathology Humans Nerve Net Neurology Neuronal Plasticity plasticity prefrontal cortex Prefrontal Cortex - physiopathology Stress, Physiological Stress, Psychological - physiopathology synapse
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Beschreibung
Zusammenfassung:	Highlights ► Stress can produce a state of anxiety that if sustained can lead to mental illness. ► Stress also alters dendrites and spines in the hippocampus, mPFC, and amygdala. ► These structural changes may underlie adaptive and maladaptive anxiety responses.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2012.04.021