Brain-derived neurotrophic factor is upregulated in the cervical dorsal root ganglia and spinal cord and contributes to the maintenance of pain from facet joint injury in the rat

The facet joint is commonly associated with neck and low back pain and is susceptible to loading‐induced injury. Although tensile loading of the cervical facet joint has been associated with inflammation and neuronal hyperexcitability, the mechanisms of joint loading‐induced pain remain unknown. Alt...

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Veröffentlicht in:Journal of neuroscience research 2013-10, Vol.91 (10), p.1312-1321
Hauptverfasser: Kras, Jeffrey V., Weisshaar, Christine L., Quindlen, Julia, Winkelstein, Beth A.
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Sprache:eng
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Zusammenfassung:The facet joint is commonly associated with neck and low back pain and is susceptible to loading‐induced injury. Although tensile loading of the cervical facet joint has been associated with inflammation and neuronal hyperexcitability, the mechanisms of joint loading‐induced pain remain unknown. Altered brain‐derived neurotrophic factor (BDNF) levels are associated with a host of painful conditions, but the role of BDNF in loading‐induced joint pain remains undefined. Separate groups of rats underwent a painful cervical facet joint distraction or a sham procedure. Bilateral forepaw mechanical hypersensitivity was assessed and BDNF mRNA and protein levels were quantified in the dorsal root ganglion (DRG) and spinal cord at days 1 and 7. Facet joint distraction induced significant (P 
ISSN:0360-4012
1097-4547
DOI:10.1002/jnr.23254