Neuronal α1/2-adrenergic stimulation of IFN-γ, IL-6, and CXCL-1 in murine spleen in late experimental arthritis

Highlight • The study demonstrates a marked change of sympathetic regulation of key cytokines in the spleen of chronic compared to acute arthritic mice.

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Bibliographische Detailangaben
Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2013-10, Vol.33, p.80-89
Hauptverfasser:	Meinel, Thomas, Pongratz, Georg, Rauch, Luise, Straub, Rainer H
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Arthritis, Experimental - diagnosis Arthritis, Experimental - immunology Arthritis, Experimental - pathology Cattle Chemokine CXCL1 - antagonists & inhibitors Chemokine CXCL1 - secretion Chronic experimental arthritis Collagen Type II - administration & dosage Collagen Type II - immunology Concanavalin A - administration & dosage Cytokines Delayed Diagnosis Electric Stimulation Female Interferon-gamma - antagonists & inhibitors Interferon-gamma - secretion Interleukin-6 - antagonists & inhibitors Interleukin-6 - secretion Mice Mice, Inbred DBA Neural Pathways - immunology Neural Pathways - secretion Neurons - pathology Neurons - secretion Neurotransmitters Psychiatry Receptor Cross-Talk - immunology Receptors, Adrenergic, alpha-1 - physiology Receptors, Adrenergic, alpha-2 - physiology Spleen Spleen - immunology Spleen - pathology Spleen - secretion Sympathetic nervous system Transforming Growth Factor beta - secretion
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Beschreibung
Zusammenfassung:	Highlight • The study demonstrates a marked change of sympathetic regulation of key cytokines in the spleen of chronic compared to acute arthritic mice.
ISSN:	0889-1591 1090-2139
DOI:	10.1016/j.bbi.2013.06.003