Testosterone and tolerance in rat vas deferens

Testosterone and tolerance in rat vas deferens

1. 1. Testosterone is able to inhibit the development of tolerance in the smooth muscle of the rat vas deferens. 2. 2. Cycloheximide and actinomycin D also inhibit the tolerance to morphine and ethanol in smooth muscle of rat vas deferens. 3. 3. The toxic effect of cycloheximide and actinomycin D do...

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Veröffentlicht in:General pharmacology 1984, Vol.15 (6), p.529-533
Hauptverfasser: Miranda, H.F., Wolstenholme, W.W.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Castration
Cycloheximide - pharmacology
Dactinomycin - pharmacology
Drug Tolerance
Ethanol - pharmacology
Male
Morphine - pharmacology
Norepinephrine - pharmacology
Rats
Rats, Inbred Strains
Testosterone - pharmacology
Vas Deferens - drug effects
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Zusammenfassung:1. 1. Testosterone is able to inhibit the development of tolerance in the smooth muscle of the rat vas deferens. 2. 2. Cycloheximide and actinomycin D also inhibit the tolerance to morphine and ethanol in smooth muscle of rat vas deferens. 3. 3. The toxic effect of cycloheximide and actinomycin D do not play roles in the inhibition of tolerance. 4. 4. The physiological responses of vas deferens to norepinephrine are not altered by cycloheximide and actinomycin D.
ISSN:0306-3623
1879-0011
DOI:10.1016/0306-3623(84)90210-6