Comparison of the Neurotoxicity of Several Chemicals Estimated by the Peripheral Nerve Conduction Velocity in Rats

Peripheral nerve conduction velocity was measured in rats exposed to lead, manganese, 2-propanol, and styrene. In rats treated with lead acetate to achieve a 5% Pb concentration, motor nerve conduction velocity (MCV) and sensory nerve conduction velocity (SCV) were significantly reduced compared to controls. In rats administered 8 mg/kg of manganese chloride, MCV rose significantly 3 weeks after the start of Mn administration, and SCV decreased slightly during the treatment period compared to controls. In rats exposed to 8000 ppm 2-propanol, MCV increased slightly and SCV increased significantly compared to controls. In the case of styrene, only SCV decreased in 2000-ppm group compared to controls. For all chemicals, conduction velocities returned to normal after the end of the administration period. Greatest effects on nerve condition velocity were seen with Pb, followed in decreasing order by styrene, 2-propanol, and Mn.