Chronic Hyperinsulinemia Does Not Increase the Production Rate of High-Density Lipoprotein Apolipoprotein AI: Evidence From a Kinetic Study in Patients With Insulinoma

OBJECTIVE—In vitro studies showed that insulin stimulates the production of apolipoprotein AI (apoAI). Thus, we hypothesized that chronic hyperinsulinemia could contribute to the increase in the production of high-density lipoprotein apoAI that is observed in metabolic syndrome. APPROACH AND RESULTS...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2013-10, Vol.33 (10), p.2460-2465
Hauptverfasser:	Duvillard, Laurence, Florentin, Emmanuel, Pont, Frédéric, Petit, Jean-Michel, Baillot-Rudoni, Sabine, Penfornis, Alfred, Vergès, Bruno
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Apolipoprotein A-I - blood Blood Glucose - metabolism Case-Control Studies Chronic Disease Female Humans Hyperinsulinism - blood Hyperinsulinism - etiology Insulin - blood Insulin Resistance Insulinoma - blood Insulinoma - complications Kinetics Lipoproteins, HDL - blood Male Metabolic Syndrome - blood Middle Aged Multivariate Analysis Pancreatic Neoplasms - blood Pancreatic Neoplasms - complications Postprandial Period Young Adult
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Zusammenfassung:	OBJECTIVE—In vitro studies showed that insulin stimulates the production of apolipoprotein AI (apoAI). Thus, we hypothesized that chronic hyperinsulinemia could contribute to the increase in the production of high-density lipoprotein apoAI that is observed in metabolic syndrome. APPROACH AND RESULTS—We performed an in vivo kinetic study with stable isotope in 7 patients with insulinoma who showed hyperinsulinemia but no insulin resistance, 8 patients with insulin resistance, and 16 controls. Insulinemia was 3.1× (P
ISSN:	1079-5642 1524-4636
DOI:	10.1161/ATVBAHA.113.301597