The second generation of iodido complexes: trans-[PtI2(amine)(amine′)] bearing different aliphatic amines

The antitumoral potential for a series of platinum iodido complexes, all bearing the same aliphatic amines (first iodido complexes generation), was demonstrated in a previous study. Concretely, cis complexes were shown to have a peculiar and different reactivity compared to cisplatin with sulfur donors models and Cyt C. In this work we have synthesized and studied iodido complexes bearing different aliphatic amines in trans configuration (the second generation) to investigate their potential antitumor activity in a panel of cell lines. Their interaction with biological models such as pBR322 and smaller biomolecules (5′-GMP, 9EtG, N-AcMet and N-AcCys) have been studied and compared to cisplatin and to the first iodido series. Their cytotoxicity, on the other hand, turned out to be especially active towards cell lines where cisplatin has no effect. The antitumoral potential for platinum iodido complexes bearing different aliphatic amines was studied. One of the complexes is especially active towards cell lines where cisplatin has no effect. These complexes' interaction with biological models such as pBR322, 5′-GMP, 9EtG, N-AcMet and N-AcCys has been studied and compared to cisplatin's [Display omitted] •Antitumoral platinum complexes bearing aliphatic amines and iodide ligands.•Cytotoxicity versus cancer cells including cisplatin-resistant cell lines.•Studies of the leaving group's effect on the reactivity with biological targets.