Nitric Oxide Releasing Photoresponsive Nanohybrids As Excellent Therapeutic Agent for Cervical Cancer Cell Lines

Gold nanoparticles (GNPs) that can release nitric oxide (NO) on visible-light irradiation were prepared using 2-mercapto-5-nitro benzimidazole (MNBI) as stabilizer. These nanoparticles meet overall prerequisites for biomedical applications like small sizes, water solubility, and stability. It was fo...

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Veröffentlicht in:	ACS applied materials & interfaces 2013-09, Vol.5 (17), p.8263-8266
Hauptverfasser:	Sudhesh, Priya, Tamilarasan, Kaviyarasan, Arumugam, Palaniappan, Berchmans, Sheela
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - drug effects Benzimidazoles - chemistry Female Gold - chemistry HeLa Cells Humans Light Metal Nanoparticles - chemistry Metal Nanoparticles - therapeutic use Metal Nanoparticles - toxicity Nitric Oxide - metabolism Solubility Uterine Cervical Neoplasms - drug therapy Uterine Cervical Neoplasms - metabolism Uterine Cervical Neoplasms - pathology Water - chemistry
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Beschreibung
Zusammenfassung:	Gold nanoparticles (GNPs) that can release nitric oxide (NO) on visible-light irradiation were prepared using 2-mercapto-5-nitro benzimidazole (MNBI) as stabilizer. These nanoparticles meet overall prerequisites for biomedical applications like small sizes, water solubility, and stability. It was found that even a very low dosage of MNBI-stabilized GNPs exhibit appreciable tumor cell mortality against cervical cancer cell lines, demonstrating the role of NO in killing cancer cells.
ISSN:	1944-8244 1944-8252
DOI:	10.1021/am402086m