Probiotic strategies for treatment of respiratory diseases

Highlights • Studies of community function and composition are necessary to identify the attributes of organisms associated with promoting mucosal health. • Ecological principles and theory can be leveraged to improve the design of self-sustaining communities of therapeutic organisms. • The sinus mu...

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Veröffentlicht in:	Trends in microbiology (Regular ed.) 2013-09, Vol.21 (9), p.485-492
Hauptverfasser:	Nagalingam, Nabeetha A, Cope, Emily K, Lynch, Susan V
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals gastrointestinal microbiota gastrointestinal system Gastrointestinal Tract - microbiology high-throughput nucleotide sequencing Humans Internal Medicine microarray technology microbial communities microbiome Microbiota minimal therapeutic community phylogeny probiotics Probiotics - therapeutic use respiratory system respiratory tract respiratory tract diseases Respiratory Tract Diseases - drug therapy sinusitus therapeutics
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Beschreibung
Zusammenfassung:	Highlights • Studies of community function and composition are necessary to identify the attributes of organisms associated with promoting mucosal health. • Ecological principles and theory can be leveraged to improve the design of self-sustaining communities of therapeutic organisms. • The sinus mucosal microbiome protects the epithelial surface from pathogen invasion. • Approaches to modulate sinus and gastrointestinal mucosal microbiota represent a powerful approach to treating disease.
ISSN:	0966-842X 1878-4380
DOI:	10.1016/j.tim.2013.04.008