Coencapsulation of Butyl-Methoxydibenzoylmethane and Octocrylene into Lipid Nanocarriers: UV Performance, Photostability and in vitro Release

The coencapsulation of two UV filters, butyl‐methoxydibenzoylmethane (BMDBM) and octocrylene (OCT), into lipid nanocarriers was explored to develop stable cosmetic formulations with broad‐spectrum photoprotection and slow release properties. Different types of nanocarriers in various concentrations of the two UV filters were tested to find the combination with the best absorption and release properties. Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) have been the two types of lipid nanocarriers used. The NLCs were based on either medium chain triglycerides (MCT) or squalene (Sq). The following physicochemical properties of the nanocarriers have been evaluated: particle size, morphology, zeta potential (ZP), entrapment efficiency, loading capacity, and thermal behavior. The nanocarriers have been formulated into creams containing low amounts of UV filters (2.5% BMDBM and 1% OCT). The best photoprotection results were obtained with the cream based on NLCs prepared with MCT, having a sun protection factor (SPF) of 17.2 and an erythemal UVA protection factor (EUVA–PF) of 50.8. The photostability of the encapsulated BMDBM filter was confirmed by subjecting the nanocarriers‐based creams to in vitro irradiation. The prolonged UV‐protection efficacy was coupled with a slow in vitro release of the synthetic UV filters, which followed the Higuchi release model. The coencapsulation of two UV filters, butyl‐methoxydibenzoylmethane (BMDBM) and octocrylene (OCT), into solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) was explored to develop stable cosmetic formulations with broad‐spectrum photoprotection and slow release properties. The lipid nanocarriers have been formulated into creams and the sun protection factor (SPF) and the erythemal UVA protection factor (EUVA–PF) of the developed cosmetic formulations were evaluated in vitro.