Immunomodulating Effects of Vilon and Its Analogue in the Culture of Human and Animal Thymus Cells

We studied molecular mechanisms of immunoprotective effects of two dipeptides, AB-O and R-1, on cultured human and rat thymic cells. Both dipeptides were shown to increase the expression of lymphocyte differentiation marker CD5 in thymic cells. Dipeptide АВ-0 induced T-cells precursor differentiation towards СD4 + T-helpers and its effect was weaker than that of dipeptide R-1. Dipeptide R-1 stimulates differentiation of CD5 + cells to mature T-helpers and cytotoxic СD8 + T cells and hence can be considered as a bioactive substance possessing immunomodulator and antiallergic activity.