Synthesis and antimicrobial activity of sulfide and sulfone derivatives of 4-(2-chloro-4-fluorophenyl)-1,3-thiazol-2-amine/acetamide

A series of 4-(2-chloro-4-fluorophenyl)-5-(4-substituted phenylsulfanyl)-thiazole-2-ylamines/acetamides ( 3a – 5b ) and 5-(4-substituted benzenesulfonyl)-4-(2-chloro-4-fluorophenyl)-thiazole-2-ylamines/acetamides ( 6a – 8b ) derivatives have been synthesized. The title compounds ( 3a – 5b ) were obtained by the nucleophilic substitution of bromo derivatives ( 2a – 2b ) with various substituted thiophenols. Structures of all the newly synthesized compounds were established by analytical and spectral data. The synthesized compounds have been screened for their antimicrobial activity against Gram-negative ( Escherichia coli ) and Gram-positive (methicillin resistant Staphylococcus aureus ) bacteria and Aspergillus niger and Candida albicans fungi.