Effect of chloroquine, methylene blue and artemether on red cell and hepatic antioxidant defence system in mice infected with Plasmodium yoelii nigeriensis

Reactive oxygen species are mediators of tissue injury and are involved in malaria infection. In this study, the status of red cell and hepatic oxidative stress and antioxidant defence indices were investigated during Plasmodium yoelii nigeriensis ( P. yoelii ) infection, and treatment with chloroqu...

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Veröffentlicht in:	Parasitology research (1987) 2013-07, Vol.112 (7), p.2619-2625
Hauptverfasser:	Nneji, Chiaka M., Adaramoye, Oluwatosin A., Falade, Catherine O., Ademowo, Olusegun G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antimalarials - therapeutic use Antioxidants Antioxidants - metabolism Artemisinins - therapeutic use Biomedical and Life Sciences Biomedicine Chloroquine Chloroquine - therapeutic use Erythrocytes - drug effects Erythrocytes - metabolism Health aspects Host-parasite relationships Immunology Liver - drug effects Liver - metabolism Malaria - drug therapy Malaria - pathology Medical Microbiology Methylene blue Methylene Blue - therapeutic use Mice Microbiology Original Paper Oxidative Stress Physiological aspects Plasmodium Plasmodium yoelii - pathogenicity Plasmodium yoelii nigeriensis
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Zusammenfassung:	Reactive oxygen species are mediators of tissue injury and are involved in malaria infection. In this study, the status of red cell and hepatic oxidative stress and antioxidant defence indices were investigated during Plasmodium yoelii nigeriensis ( P. yoelii ) infection, and treatment with chloroquine (CQ), methylene blue (MB) or artemether (ART) in mice. P. yoelii infection caused a significant ( p MB. CQ, MB and ART treatment of infected mice caused a significant ( p
ISSN:	0932-0113 1432-1955
DOI:	10.1007/s00436-013-3426-z