Cerebral alteration in calmodulin levels associated with the induction of physical dependence upon ethanol in rats

Calmodulin levels were measured in different areas of brain in rats rendered physically dependent and after single doses (6 g/kg) of ethanol. After single doses of ethanol no changes in the calmodulin levels were found in the cortex, but those in the hippocampus and caudate nuclei were increased whi...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Brain research 1985-09, Vol.342 (2), p.379-381
Hauptverfasser:	Pant, Harish C., Majchrowicz, Edward, Virmani, Mridulika
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcoholism and acute alcohol poisoning Animals Biological and medical sciences brain Brain - metabolism calmodulin Calmodulin - metabolism Caudate Nucleus - metabolism Cerebellum - metabolism Cerebral Cortex - metabolism Ethanol - adverse effects ethanol dependence Hippocampus - metabolism Male Medical sciences Rats Rats, Inbred Strains Substance Withdrawal Syndrome - metabolism Substance-Related Disorders - metabolism Toxicology withdrawal syndrome
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Calmodulin levels were measured in different areas of brain in rats rendered physically dependent and after single doses (6 g/kg) of ethanol. After single doses of ethanol no changes in the calmodulin levels were found in the cortex, but those in the hippocampus and caudate nuclei were increased while those in the cerebellum were reduced. In the dependent intoxicated (prodromal) rats, calmodulin levels were elevated in all these brain regions except the cerebellum. In rats undergoing ethanol withdrawal syndrome, the calmodulin levels decreased in all regions of the brain except caudate nuclei.
ISSN:	0006-8993 1872-6240
DOI:	10.1016/0006-8993(85)91141-2