Metabolism, distribution, and excretion of deltamethrin by Leghorn hens

Studies were conducted to determine the metabolic fate of deltamethrin in Leghorn hens. The birds were administered orally super(14)C-labeled (gem-dimethyl or benzyl) deltamethrin/hen/day on each of three consecutive days, and the elimination of radiocarbon ( super(14)C) in excreta and eggs was monitored. About 83% of the administered super(14)C was eliminated during the first 24 h after dosing. Residues derived from the gem-dimethyl portion of the molecule tended to be higher than those from the benzyl moiety. Egg yolks contained considerably higher levels of residues than egg albumen. Various metabolites were isolated and compounds identified indicated that the metabolic routes of deltamethrin in laying hens include hydrolysis of ester linkage, followed by hydroxylation of one or both gem-dimethyl groups, hydroxylation of the 2'-, 4'-, 5-, or 6-position of the phenoxybenzyl moiety.