Refeeding syndrome in very-low-birth-weight intrauterine growth-restricted neonates

Objective: Determine the incidence of refeeding syndrome, defined by the presence of hypophosphatemia in very-low-birth-weight (VLBW) infants with intrauterine growth restriction (IUGR) compared with those without IUGR. Study design: In this retrospective cohort study, VLBW infants admitted over a 1...

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Veröffentlicht in:Journal of perinatology 2013-09, Vol.33 (9), p.717-720
Hauptverfasser: Ross, J R, Finch, C, Ebeling, M, Taylor, S N
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Sprache:eng
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Zusammenfassung:Objective: Determine the incidence of refeeding syndrome, defined by the presence of hypophosphatemia in very-low-birth-weight (VLBW) infants with intrauterine growth restriction (IUGR) compared with those without IUGR. Study design: In this retrospective cohort study, VLBW infants admitted over a 10-year period (271 IUGR and 1982 non-IUGR) were evaluated for specific electrolyte abnormalities in the first postnatal week. Result: IUGR infants were significantly more likely to have hypophosphatemia (41% vs 8.9%, relative risk (95% confidence interval: 7.25 (5.45, 9.65)) and severe hypophosphatemia (11.4% vs 1%, 12.06 (6.82, 21.33)) in the first postnatal week. The incidence of hypophosphatemia was significantly associated with the presence of maternal preeclampsia in all VLBW infants (odds ratio (OR): 2.58 (1.96, 3.40)) when controlling for birth weight and gestational age. Conclusion: Refeeding syndrome occurs in VLBW infants with IUGR and born to mothers with preeclampsia. Close monitoring of electrolytes, especially phosphorus, is warranted in this population.
ISSN:0743-8346
1476-5543
DOI:10.1038/jp.2013.28