Effects of Serum Testosterone Levels After 6 Months of Androgen Deprivation Therapy on the Outcome of Patients With Prostate Cancer

Micro-Abstract Androgen deprivation therapy (ADT) is administered in patients with locally advanced metastatic disease, those with high-risk localized disease, and those with biochemical failure. The goal is to induce a profound drop in plasma testosterone levels. This study confirms that serum test...

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Veröffentlicht in:	Clinical genitourinary cancer 2013-09, Vol.11 (3), p.325-330.e1
Hauptverfasser:	Bertaglia, Valentina, Tucci, Marcello, Fiori, Cristian, Aroasio, Emiliano, Poggio, Massimiliano, Buttigliero, Consuelo, Grande, Susanna, Saini, Andrea, Porpiglia, Francesco, Berruti, Alfredo
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Androgen Antagonists - therapeutic use Antineoplastic Agents, Hormonal - therapeutic use Biomarkers - blood Gonadotropin-Releasing Hormone - analogs & derivatives Hematology, Oncology and Palliative Medicine Hormonal therapy Humans Male Middle Aged Prognosis Prospective Studies Prostate cancer Prostatic Neoplasms - blood Prostatic Neoplasms - drug therapy Prostatic Neoplasms - mortality Survival Testosterone Testosterone - blood Treatment Outcome Urology
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Zusammenfassung:	Micro-Abstract Androgen deprivation therapy (ADT) is administered in patients with locally advanced metastatic disease, those with high-risk localized disease, and those with biochemical failure. The goal is to induce a profound drop in plasma testosterone levels. This study confirms that serum testosterone levels have a prognostic role in patients with prostate cancer receiving ADT. Serum testosterone levels lower than the currently adopted cutoff seem to be associated with prognosis.
ISSN:	1558-7673 1938-0682
DOI:	10.1016/j.clgc.2013.01.002