Chloroquine: Modes of action of an undervalued drug

Highlights • Chloroquine, an antimalarial drug, can also be used in the manipulation of the immune system. • This review demonstrates the multitude of actions displayed by CQ, dependent on lysosome dysfunction and also pH-independent mechanisms. • Chloroquine administration ameliorates rheumatoid ar...

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Veröffentlicht in:	Immunology letters 2013-06, Vol.153 (1), p.50-57
Hauptverfasser:	Thomé, Rodolfo, Lopes, Stefanie Costa Pinto, Costa, Fabio Trindade Maranhão, Verinaud, Liana
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Anti-Inflammatory Agents - therapeutic use Arthritis, Rheumatoid - drug therapy Autoimmunity Chloroquine Chloroquine - adverse effects Chloroquine - therapeutic use Drug Resistance, Bacterial - genetics Eye - drug effects Humans Immunosuppressive Agents - therapeutic use Lysosomes - drug effects Malaria Malaria - drug therapy Plasmodium - drug effects Plasmodium - genetics Transplantation Transplantation Immunology
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Zusammenfassung:	Highlights • Chloroquine, an antimalarial drug, can also be used in the manipulation of the immune system. • This review demonstrates the multitude of actions displayed by CQ, dependent on lysosome dysfunction and also pH-independent mechanisms. • Chloroquine administration ameliorates rheumatoid arthritis, systemic lupus and viral infections.
ISSN:	0165-2478 1879-0542
DOI:	10.1016/j.imlet.2013.07.004